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Tumour tissues displayed moderate cytoplasmic positivity with additional nuclear staining in many cases. Several breast, prostate, testicular and hepatocellular carcinomas were strongly stained.
A majority of malignancies showed moderate cytoplasmic positivity with cases of nuclear staining. Several cases of colorectal and breast cancer as well as a few cases of ovarian, thyroid and head and neck cancers were strongly stained. Remaining malignant cells were weakly stained or negative.
GENE INFORMATION
Gene name
RMND1 (HGNC Symbol)
Synonyms
bA351K16.3, C6orf96, FLJ20627, RMD1
Description
Required for meiotic nuclear division 1 homolog (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]