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Several cases of urothelial and renal cancers displayed moderate cytoplasmic staining while fractions of cases in several cancers including malignant melanomas and lymphomas showed distinct nuclear and cytoplasmic immunoreactivity. Cancer tissues in general were weakly stained or negative.
GENE INFORMATION
Gene name
MAGEA8 (HGNC Symbol)
Synonyms
CT1.8, MAGE8, MGC2182
Description
Melanoma antigen family A8 (HGNC Symbol)
Entrez gene summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]