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MCU

GENERAL INFORMATION

Gene name

 MCU

Gene description

 Mitochondrial calcium uniporter

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA016480
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MCU (HGNC Symbol)

Synonyms

 C10orf42, CCDC109A, FLJ46135

Description

 Mitochondrial calcium uniporter (HGNC Symbol)

Entrez gene summary

 This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 72692131 - 72887694

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156026 (version 83.38)

Entrez gene

 90550

UniProt

 Q8NE86 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NE86

Antibodypedia

 MCU antibodies

PROTEIN BROWSER
MCU-001
MCU-002
MCU-008
MCU-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCU-001
ENSP00000349680
ENST00000357157
Q8NE86 [Direct mapping]
Calcium uniporter protein, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006851 [mitochondrial calcium ion transport]
GO:0015292 [uniporter activity]
GO:0019722 [calcium-mediated signaling]
GO:0031305 [integral component of mitochondrial inner membrane]
GO:0032024 [positive regulation of insulin secretion]
GO:0034704 [calcium channel complex]
GO:0035786 [protein complex oligomerization]
GO:0036444 [calcium ion transmembrane import into mitochondrion]
GO:0042593 [glucose homeostasis]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:1990246 [uniplex complex]
Show all
 330 aa
37 kDa 		Yes 2
MCU-002
ENSP00000362144
ENST00000373053
Q8NE86 [Direct mapping]
Calcium uniporter protein, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006851 [mitochondrial calcium ion transport]
GO:0015292 [uniporter activity]
GO:0019722 [calcium-mediated signaling]
GO:0031305 [integral component of mitochondrial inner membrane]
GO:0032024 [positive regulation of insulin secretion]
GO:0034704 [calcium channel complex]
GO:0035786 [protein complex oligomerization]
GO:0036444 [calcium ion transmembrane import into mitochondrion]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:1990246 [uniplex complex]
Show all
 351 aa
39.9 kDa 		Yes 2
MCU-008
ENSP00000475141
ENST00000604152
S4R468 [Direct mapping]
Calcium uniporter protein, mitochondrial
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 167 aa
19 kDa 		No 0
MCU-201
ENSP00000440913
ENST00000536019
Q8NE86 [Direct mapping]
Calcium uniporter protein, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006851 [mitochondrial calcium ion transport]
GO:0015292 [uniporter activity]
GO:0019722 [calcium-mediated signaling]
GO:0031305 [integral component of mitochondrial inner membrane]
GO:0032024 [positive regulation of insulin secretion]
GO:0034704 [calcium channel complex]
GO:0035786 [protein complex oligomerization]
GO:0036444 [calcium ion transmembrane import into mitochondrion]
GO:0042593 [glucose homeostasis]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:1990246 [uniplex complex]
Show all
 302 aa
35.2 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.