Expression of UGT2B4 in cancer - Summary - The Human Protein Atlas

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UGT2B4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UGT2B4
Gene description	UDP glucuronosyltransferase 2 family, polypeptide B4
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (RH-30)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression most abundant in liver and kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA045108 , CAB033260
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045108	CAB033260

GENE INFORMATION
Gene name	UGT2B4 (HGNC Symbol)
Synonyms	UGT2B11
Description	UDP glucuronosyltransferase 2 family, polypeptide B4 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	69480165 - 69526014
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156096 (version 83.38)
Entrez gene	7363
UniProt	P06133 (UniProt - Evidence at protein level)
neXtProt	NX_P06133
Antibodypedia	UGT2B4 antibodies

PROTEIN BROWSER

UGT2B4-001	UGT2B4-002	UGT2B4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UGT2B4-001 ENSP00000305221 ENST00000305107	P06133 [Direct mapping] UDP-glucuronosyltransferase 2B4 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006711 [estrogen catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052695 [cellular glucuronidation] GO:0052696 [flavonoid glucuronidation] Show all	528 aa 60.5 kDa	Yes	1
UGT2B4-002 ENSP00000421290 ENST00000512583	P06133 [Direct mapping] UDP-glucuronosyltransferase 2B4 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006711 [estrogen catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052695 [cellular glucuronidation] GO:0052696 [flavonoid glucuronidation] Show all	369 aa 42.7 kDa	Yes	0
UGT2B4-004 ENSP00000421113 ENST00000510114	D6RGY0 [Direct mapping] UDP-glucuronosyltransferase 2B4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	54 aa 6.2 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.