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ADK

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GENERAL INFORMATION

Gene name

 ADK

Gene description

 Adenosine kinase

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA038409
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported)

Additional location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038409 A-431 No staining    
HPA038409 PC-3 Nucleoplasm
Cytosol
HPA038409 U-2 OS No staining    

GENE INFORMATION

Gene name

 ADK (HGNC Symbol)

Synonyms

 AK

Description

 Adenosine kinase (HGNC Symbol)

Entrez gene summary

 This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 10

Cytoband

 q22.2

Chromosome location (bp)

 74151185 - 74709303

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156110 (version 83.38)

Entrez gene

 132

UniProt

 P55263 (UniProt - Evidence at protein level)

neXtProt

 NX_P55263

Antibodypedia

 ADK antibodies

PROTEIN BROWSER
ADK-001
ADK-003
ADK-201
ADK-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADK-001
ENSP00000286621
ENST00000286621
P55263 [Direct mapping]
Adenosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004001 [adenosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006166 [purine ribonucleoside salvage]
GO:0006175 [dATP biosynthetic process]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0032922 [circadian regulation of gene expression]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043101 [purine-containing compound salvage]
GO:0044209 [AMP salvage]
GO:0044281 [small molecule metabolic process]
GO:0044342 [type B pancreatic cell proliferation]
GO:0044822 [poly(A) RNA binding]
GO:0046085 [adenosine metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 362 aa
40.5 kDa 		No 0
ADK-003
ENSP00000361819
ENST00000372734
P55263 [Direct mapping]
Adenosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004001 [adenosine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0043101 [purine-containing compound salvage]
GO:0044209 [AMP salvage]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 345 aa
38.7 kDa 		No 0
ADK-201
ENSP00000443965
ENST00000539909
P55263 [Direct mapping]
Adenosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004001 [adenosine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0043101 [purine-containing compound salvage]
GO:0044209 [AMP salvage]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 305 aa
34.1 kDa 		No 0
ADK-202
ENSP00000438321
ENST00000541550
P55263 [Direct mapping]
Adenosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004001 [adenosine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0043101 [purine-containing compound salvage]
GO:0044209 [AMP salvage]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 327 aa
36.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.