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Fraction of tumor cells in rare case of duct carcinoma of breast and pancreatic cancer showed weak to moderate membranous positivity. Remaining cancer tissues negative.
The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding]