Expression of ADAMTSL3 in cancer - Summary - The Human Protein Atlas

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ADAMTSL3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAMTSL3
Gene description	ADAMTS-like 3
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (EFO-21, RPTEC TERT1, TIME, U-2 OS)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA034773 , HPA034774
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034773	HPA034774

GENE INFORMATION
Gene name	ADAMTSL3 (HGNC Symbol)
Synonyms	KIAA1233, punctin-2
Description	ADAMTS-like 3 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q25.2
Chromosome location (bp)	83654086 - 84039842
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156218 (version 83.38)
Entrez gene	57188
UniProt	P82987 (UniProt - Evidence at protein level)
neXtProt	NX_P82987
Antibodypedia	ADAMTSL3 antibodies

PROTEIN BROWSER

ADAMTSL3-001	ADAMTSL3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTSL3-001 ENSP00000286744 ENST00000286744	P82987 [Direct mapping] ADAMTS-like protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	1691 aa 188.7 kDa	Yes	0
ADAMTSL3-002 ENSP00000456313 ENST00000567476	P82987 [Direct mapping] ADAMTS-like protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	1682 aa 187.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.