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WHAMM

GENERAL INFORMATION

Gene name

 WHAMM

Gene description

 WAS protein homolog associated with actin, golgi membranes and microtubules

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression most abundant in neurons and the large intestine.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039690 , HPA040231
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable) and cervical cancer (favourable).
Prostate cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039690
HPA040231

GENE INFORMATION

Gene name

 WHAMM (HGNC Symbol)

Synonyms

 KIAA1971, WHAMM1, WHDC1

Description

 WAS protein homolog associated with actin, golgi membranes and microtubules (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]

Chromosome

 15

Cytoband

 q25.2

Chromosome location (bp)

 82809628 - 82836108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156232 (version 83.38)

Entrez gene

 123720

UniProt

 Q8TF30 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TF30

Antibodypedia

 WHAMM antibodies

PROTEIN BROWSER
WHAMM-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WHAMM-001
ENSP00000286760
ENST00000286760
Q8TF30 [Direct mapping]
WASP homolog-associated protein with actin, membranes and microtubules
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007015 [actin filament organization]
GO:0008017 [microtubule binding]
GO:0017049 [GTP-Rho binding]
GO:0030032 [lamellipodium assembly]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0048041 [focal adhesion assembly]
GO:0051127 [positive regulation of actin nucleation]
GO:0071933 [Arp2/3 complex binding]
GO:0090527 [actin filament reorganization]
GO:0097320 [membrane tubulation]
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 809 aa
90.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.