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USP16

GENERAL INFORMATION

Gene name

 USP16

Gene description

 Ubiquitin specific peptidase 16

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA021140
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA021140

GENE INFORMATION

Gene name

 USP16 (HGNC Symbol)

Synonyms

 Ubp-M

Description

 Ubiquitin specific peptidase 16 (HGNC Symbol)

Entrez gene summary

 This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 29024629 - 29054488

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156256 (version 83.38)

Entrez gene

 10600

UniProt

 Q9Y5T5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5T5

Antibodypedia

 USP16 antibodies

PROTEIN BROWSER
USP16-001
USP16-002
USP16-003
USP16-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP16-001
ENSP00000382857
ENST00000399975
Q9Y5T5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 16
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0035522 [monoubiquitinated histone H2A deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042393 [histone binding]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045901 [positive regulation of translational elongation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051289 [protein homotetramerization]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070537 [histone H2A K63-linked deubiquitination]
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 822 aa
93.5 kDa 		No 0
USP16-002
ENSP00000382858
ENST00000399976
Q9Y5T5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 16
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0035522 [monoubiquitinated histone H2A deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042393 [histone binding]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045901 [positive regulation of translational elongation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051289 [protein homotetramerization]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070537 [histone H2A K63-linked deubiquitination]
Show all
 823 aa
93.6 kDa 		No 0
USP16-003
ENSP00000334808
ENST00000334352
Q9Y5T5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 16
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0035522 [monoubiquitinated histone H2A deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042393 [histone binding]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045901 [positive regulation of translational elongation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051289 [protein homotetramerization]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070537 [histone H2A K63-linked deubiquitination]
Show all
 823 aa
93.6 kDa 		No 0
USP16-006
ENSP00000382855
ENST00000399973
H9KVB6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 107 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.