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CLDN17

GENERAL INFORMATION

Gene name

 CLDN17

Gene description

 Claudin 17

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (esophagus)
GTEx:Group enriched (cervix, uterine, esophagus, salivary gland, vagina)
FANTOM5:Tissue enhanced (cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in oral mucosa and esophagus.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA045903
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, salivary gland, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine)

GENE INFORMATION

Gene name

 CLDN17 (HGNC Symbol)

Synonyms

 MGC126552, MGC126554

Description

 Claudin 17 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 30165564 - 30166756

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156282 (version 83.38)

Entrez gene

 26285

UniProt

 P56750 (UniProt - Evidence at transcript level)

neXtProt

 NX_P56750

Antibodypedia

 CLDN17 antibodies

PROTEIN BROWSER
CLDN17-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLDN17-001
ENSP00000286808
ENST00000286808
P56750 [Direct mapping]
Claudin-17
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
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GO:0005198 [structural molecule activity]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0016021 [integral component of membrane]
GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules]
GO:0034329 [cell junction assembly]
GO:0042802 [identical protein binding]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
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 224 aa
24.6 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.