Expression of TSPAN7 in cancer - Summary

GENERAL INFORMATION
Gene name	TSPAN7
Gene description	Tetraspanin 7
Protein class	CD markers Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2, MOLT-4, SCLC-21H, U-266/70)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in islets of Langerhans, CNS and enteroendocrine cells in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification. Paired antibodies with high similarity supports the protein profile.
Reliability score	Supported based on 3 antibodies. HPA003140 , CAB062566 , CAB068245
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA003140	CAB062566	CAB068245

GENE INFORMATION
Gene name	TSPAN7 (HGNC Symbol)
Synonyms	A15, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2
Description	Tetraspanin 7 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.4
Chromosome location (bp)	38561370 - 38688920
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156298 (version 83.38)
Entrez gene	7102
UniProt	P41732 (UniProt - Evidence at protein level)
neXtProt	NX_P41732
Antibodypedia	TSPAN7 antibodies

PROTEIN BROWSER

TSPAN7-001	TSPAN7-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSPAN7-001 ENSP00000367743 ENST00000378482	P41732 [Direct mapping] Tetraspanin-7 Show all	CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016032 [viral process] Show all	249 aa 27.6 kDa	No	4
TSPAN7-005 ENSP00000286824 ENST00000286824	B4DDG0 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	266 aa 29.4 kDa	No	5