Cell atlas - PTDSS1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PTDSS1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Nucleoplasm

Human cell
	Endoplasmic Reticulum
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PTDSS1
Gene description	Phosphatidylserine synthase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA016852
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum. In addition localized to the nucleoplasm.

Main location

Endoplasmic reticulum (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA016852	A-431	Endoplasmic reticulum
	HPA016852	U-2 OS	Nucleoplasm
	HPA016852	U-2 OS	Endoplasmic reticulum
	HPA016852	U-251 MG	Nucleoplasm
	HPA016852	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	PTDSS1 (HGNC Symbol)
Synonyms	KIAA0024, PSS1, PSSA
Description	Phosphatidylserine synthase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Chromosome	8
Cytoband	q22.1
Chromosome location (bp)	96261715 - 96336995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156471 (version 83.38)
Entrez gene	9791
UniProt	P48651 (UniProt - Evidence at protein level)
neXtProt	NX_P48651
Antibodypedia	PTDSS1 antibodies

PROTEIN BROWSER

PTDSS1-001	PTDSS1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTDSS1-001 ENSP00000430548 ENST00000517309	P48651 [Direct mapping] Phosphatidylserine synthase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006659 [phosphatidylserine biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	473 aa 55.5 kDa	No	9
PTDSS1-003 ENSP00000430928 ENST00000522072	P48651 [Direct mapping] Phosphatidylserine synthase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006659 [phosphatidylserine biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	301 aa 34.6 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.