Cell atlas - PPP2R2B - The Human Protein Atlas

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PPP2R2B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PPP2R2B
Gene description	Protein phosphatase 2, regulatory subunit B, beta
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (HDLM-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042122
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042122	A-431	Cytosol
	HPA042122	U-2 OS	No staining
	HPA042122	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PPP2R2B (HGNC Symbol)
Synonyms	PR52B, PR55-BETA, SCA12
Description	Protein phosphatase 2, regulatory subunit B, beta (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	146581146 - 147084784
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156475 (version 83.38)
Entrez gene	5521
UniProt	Q00005 (UniProt - Evidence at protein level)
neXtProt	NX_Q00005
Antibodypedia	PPP2R2B antibodies

PROTEIN BROWSER

PPP2R2B-001	PPP2R2B-002	PPP2R2B-003	PPP2R2B-008	PPP2R2B-009	PPP2R2B-011	PPP2R2B-013	PPP2R2B-017	PPP2R2B-020	PPP2R2B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP2R2B-001 ENSP00000377936 ENST00000394414	Q00005 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005856 [cytoskeleton] GO:0006915 [apoptotic process] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	509 aa 58.9 kDa	No	0
PPP2R2B-002 ENSP00000377931 ENST00000394409	Q00005 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005856 [cytoskeleton] GO:0006915 [apoptotic process] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	443 aa 51.7 kDa	No	0
PPP2R2B-003 ENSP00000336591 ENST00000336640	Q00005 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005856 [cytoskeleton] GO:0006915 [apoptotic process] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	446 aa 52 kDa	No	0
PPP2R2B-008 ENSP00000431320 ENST00000508545	Q00005 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005856 [cytoskeleton] GO:0006915 [apoptotic process] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	432 aa 50.4 kDa	No	0
PPP2R2B-009 ENSP00000421396 ENST00000504198	Q00005 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005856 [cytoskeleton] GO:0006915 [apoptotic process] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	449 aa 52.1 kDa	No	0
PPP2R2B-011 ENSP00000421224 ENST00000508267	D6RGF9 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	58 aa 6.7 kDa	No	0
PPP2R2B-013 ENSP00000425828 ENST00000512984	H0YA16 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	78 aa 9.2 kDa	No	0
PPP2R2B-017 ENSP00000377933 ENST00000394411	Q00005 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005856 [cytoskeleton] GO:0006915 [apoptotic process] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	443 aa 51.7 kDa	No	0
PPP2R2B-020 ENSP00000377935 ENST00000394413	Q00005 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005856 [cytoskeleton] GO:0006915 [apoptotic process] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	501 aa 58.2 kDa	No	0
PPP2R2B-201 ENSP00000398779 ENST00000453001	Q00005 [Direct mapping] Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005856 [cytoskeleton] GO:0006915 [apoptotic process] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity] Show all	432 aa 50.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.