Cell atlas - HKDC1 - The Human Protein Atlas

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HKDC1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	HKDC1
Gene description	Hexokinase domain containing 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Group enriched (CAPAN-2, RPTEC TERT1, CACO-2, A549, EFO-21, Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA064198 , HPA064230
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (CAPAN-2, RPTEC TERT1, CACO-2, A549, EFO-21, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064198	A549	Mitochondria
	HPA064198	CACO-2	Mitochondria	Intensity
	HPA064230	A549	Mitochondria
	HPA064230	CACO-2	Mitochondria
	HPA064230	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	HKDC1 (HGNC Symbol)
Synonyms	FLJ22761, FLJ37767
Description	Hexokinase domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	69220303 - 69267559
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156510 (version 83.38)
Entrez gene	80201
UniProt	Q2TB90 (UniProt - Evidence at protein level)
neXtProt	NX_Q2TB90
Antibodypedia	HKDC1 antibodies

PROTEIN BROWSER

HKDC1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HKDC1-001 ENSP00000346643 ENST00000354624	Q2TB90 [Direct mapping] Putative hexokinase HKDC1 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001678 [cellular glucose homeostasis] GO:0004340 [glucokinase activity] GO:0004396 [hexokinase activity] GO:0005524 [ATP binding] GO:0005536 [glucose binding] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006096 [glycolytic process] GO:0008865 [fructokinase activity] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0019158 [mannokinase activity] GO:0019318 [hexose metabolic process] GO:0046835 [carbohydrate phosphorylation] GO:0051156 [glucose 6-phosphate metabolic process] Show all	917 aa 102.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.