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HK1

GENERAL INFORMATION

Gene name

 HK1

Gene description

 Hexokinase 1

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (K-562)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA007043 , HPA007044 , HPA011956 , CAB010052
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007043
HPA007044
HPA011956
CAB010052

GENE INFORMATION

Gene name

 HK1

Synonyms

Description

 Hexokinase 1 (HGNC Symbol)

Entrez gene summary

 Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 69269984 - 69401882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156515 (version 83.38)

Entrez gene

 3098

UniProt

 P19367 (UniProt - Evidence at protein level)

neXtProt

 NX_P19367

Antibodypedia

 HK1 antibodies

PROTEIN BROWSER
HK1-001
HK1-003
HK1-004
HK1-016
HK1-201
HK1-202
HK1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HK1-001
ENSP00000352398
ENST00000359426
P19367 [Direct mapping]
Hexokinase-1
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008645 [hexose transport]
GO:0008865 [fructokinase activity]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:1903599 [positive regulation of mitophagy]
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 917 aa
102.5 kDa 		No 0
HK1-003
ENSP00000409761
ENST00000450646
B1AR61 [Direct mapping]
Hexokinase-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0008865 [fructokinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
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 139 aa
15.7 kDa 		No 0
HK1-004
ENSP00000398316
ENST00000421088
B1AR62 [Direct mapping]
Hexokinase-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0008865 [fructokinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
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 114 aa
13 kDa 		No 0
HK1-016
ENSP00000415949
ENST00000436817
B1AR63 [Direct mapping]
Hexokinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0008865 [fructokinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
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 291 aa
32.7 kDa 		No 0
HK1-201
ENSP00000298649
ENST00000298649
P19367 [Direct mapping]
Hexokinase-1
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008645 [hexose transport]
GO:0008865 [fructokinase activity]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:1903599 [positive regulation of mitophagy]
Show all
 916 aa
102.2 kDa 		No 0
HK1-202
ENSP00000353433
ENST00000360289
P19367 [Direct mapping]
Hexokinase-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008645 [hexose transport]
GO:0008865 [fructokinase activity]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:1903599 [positive regulation of mitophagy]
Show all
 905 aa
101.1 kDa 		No 0
HK1-203
ENSP00000402103
ENST00000448642
P19367 [Direct mapping]
Hexokinase-1
A0A024QZK7 [Target identity:100%; Query identity:100%]
Hexokinase
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008645 [hexose transport]
GO:0008865 [fructokinase activity]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019158 [mannokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0046835 [carbohydrate phosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0097228 [sperm principal piece]
GO:1903599 [positive regulation of mitophagy]
Show all
 921 aa
102.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.