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PRG3

GENERAL INFORMATION

Gene name

 PRG3

Gene description

 Proteoglycan 3

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in a subset of hematopoietic cells in bone marrow.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA064183
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA064183

GENE INFORMATION

Gene name

 PRG3 (HGNC Symbol)

Synonyms

 MBPH

Description

 Proteoglycan 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 57376769 - 57381150

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156575 (version 83.38)

Entrez gene

 10394

UniProt

 Q9Y2Y8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2Y8

Antibodypedia

 PRG3 antibodies

PROTEIN BROWSER
PRG3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRG3-001
ENSP00000287143
ENST00000287143
Q9Y2Y8 [Direct mapping]
Proteoglycan 3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001694 [histamine biosynthetic process]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0017148 [negative regulation of translation]
GO:0019370 [leukotriene biosynthetic process]
GO:0030246 [carbohydrate binding]
GO:0042119 [neutrophil activation]
GO:0042554 [superoxide anion generation]
GO:0045416 [positive regulation of interleukin-8 biosynthetic process]
GO:0045575 [basophil activation]
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 225 aa
25.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.