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MED19

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GENERAL INFORMATION

Gene name

 MED19

Gene description

 Mediator complex subunit 19

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (supported)

Additional location

 In addition localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA039912 , HPA040860
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleus.

Main location

 Nuclear bodies (supported)

Additional location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039912 A-431 Nucleus
HPA039912 U-251 MG Nucleus
Nuclear bodies
HPA040860 A-431 Nuclear bodies
HPA040860 U-2 OS Nuclear bodies
HPA040860 U-251 MG Nuclear bodies

GENE INFORMATION

Gene name

 MED19 (HGNC Symbol)

Synonyms

 LCMR1

Description

 Mediator complex subunit 19 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 57703714 - 57712221

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156603 (version 83.38)

Entrez gene

 219541

UniProt

 A0JLT2 (UniProt - Evidence at protein level)

neXtProt

 NX_A0JLT2

Antibodypedia

 MED19 antibodies

PROTEIN BROWSER
MED19-001
MED19-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED19-001
ENSP00000337340
ENST00000337672
A0JLT2 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 19
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
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 194 aa
20.4 kDa 		No 0
MED19-002
ENSP00000416227
ENST00000431606
J3KR33 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 19
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 244 aa
26.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.