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BAG4

GENERAL INFORMATION

Gene name

 BAG4

Gene description

 BCL2-associated athanogene 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA018951 , CAB013716
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA018951
CAB013716

GENE INFORMATION

Gene name

 BAG4 (HGNC Symbol)

Synonyms

 SODD

Description

 BCL2-associated athanogene 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Chromosome

 8

Cytoband

 p11.23

Chromosome location (bp)

 38176533 - 38213301

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156735 (version 83.38)

Entrez gene

 9530

UniProt

 O95429 (UniProt - Evidence at protein level)

neXtProt

 NX_O95429

Antibodypedia

 BAG4 antibodies

PROTEIN BROWSER
BAG4-001
BAG4-002
BAG4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BAG4-001
ENSP00000287322
ENST00000287322
O95429 [Direct mapping]
BAG family molecular chaperone regulator 4
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010763 [positive regulation of fibroblast migration]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034605 [cellular response to heat]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045785 [positive regulation of cell adhesion]
GO:0051087 [chaperone binding]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0072659 [protein localization to plasma membrane]
GO:0097178 [ruffle assembly]
GO:1900034 [regulation of cellular response to heat]
GO:1903215 [negative regulation of protein targeting to mitochondrion]
GO:2001145 [negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity]
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 457 aa
49.6 kDa 		No 0
BAG4-002
ENSP00000393298
ENST00000432471
O95429 [Direct mapping]
BAG family molecular chaperone regulator 4
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0007166 [cell surface receptor signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034605 [cellular response to heat]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0051087 [chaperone binding]
GO:0071356 [cellular response to tumor necrosis factor]
GO:1900034 [regulation of cellular response to heat]
GO:1903215 [negative regulation of protein targeting to mitochondrion]
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 421 aa
45.4 kDa 		No 0
BAG4-004
ENSP00000430250
ENST00000521311
H0YBT1 [Direct mapping]
BAG family molecular chaperone regulator 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 155 aa
16.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.