Expression of VPS8 in cancer - Summary - The Human Protein Atlas

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VPS8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	VPS8
Gene description	Vacuolar protein sorting 8 homolog (S. cerevisiae)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression i most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA036871
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036871

GENE INFORMATION
Gene name	VPS8 (HGNC Symbol)
Synonyms	FLJ32099, KIAA0804
Description	Vacuolar protein sorting 8 homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q27.2
Chromosome location (bp)	184812143 - 185052614
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156931 (version 83.38)
Entrez gene	23355
UniProt	Q8N3P4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N3P4
Antibodypedia	VPS8 antibodies

PROTEIN BROWSER

VPS8-002	VPS8-003	VPS8-004	VPS8-005	VPS8-008	VPS8-009	VPS8-010	VPS8-012	VPS8-027	VPS8-201	VPS8-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VPS8-002 ENSP00000404704 ENST00000436792	Q8N3P4 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0008270 [zinc ion binding] GO:0015031 [protein transport] GO:0034058 [endosomal vesicle fusion] Show all	1426 aa 161.6 kDa	No	0
VPS8-003 ENSP00000405483 ENST00000446204	Q8N3P4 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0008270 [zinc ion binding] GO:0015031 [protein transport] GO:0034058 [endosomal vesicle fusion] Show all	1336 aa 151.2 kDa	No	0
VPS8-004 ENSP00000389480 ENST00000424463	C9JP71 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18.2 kDa	No	0
VPS8-005 ENSP00000416101 ENST00000426319	H7C490 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.7 kDa	No	0
VPS8-008 ENSP00000394018 ENST00000453056	C9JKL0 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.6 kDa	No	0
VPS8-009 ENSP00000409957 ENST00000441141	C9JPI1 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 15.9 kDa	No	0
VPS8-010 ENSP00000415161 ENST00000422105	C9JG07 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		202 aa 21.9 kDa	No	0
VPS8-012 ENSP00000416150 ENST00000445089	C9JIA0 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 13.8 kDa	No	0
VPS8-027 ENSP00000487164 ENST00000625842	Q8N3P4 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0008270 [zinc ion binding] GO:0015031 [protein transport] GO:0033263 [CORVET complex] GO:0034058 [endosomal vesicle fusion] Show all	1428 aa 161.8 kDa	No	0
VPS8-201 ENSP00000287546 ENST00000287546	C9JJN9 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	1428 aa 161.8 kDa	No	0
VPS8-202 ENSP00000487080 ENST00000628962	F8WB24 [Direct mapping] Vacuolar protein sorting-associated protein 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.