Cell atlas - EIF4A2 - The Human Protein Atlas

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EIF4A2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	EIF4A2
Gene description	Eukaryotic translation initiation factor 4A2
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA068286
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA068286	CACO-2	Cytosol
	HPA068286	U-2 OS	Cytosol
	HPA068286	U-251 MG	Cytosol

GENE INFORMATION
Gene name	EIF4A2 (HGNC Symbol)
Synonyms	BM-010, DDX2B, EIF4A, EIF4F
Description	Eukaryotic translation initiation factor 4A2 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q27.3
Chromosome location (bp)	186783205 - 186789900
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156976 (version 83.38)
Entrez gene	1974
UniProt	Q14240 (UniProt - Evidence at protein level)
neXtProt	NX_Q14240
Antibodypedia	EIF4A2 antibodies

PROTEIN BROWSER

EIF4A2-001	EIF4A2-004	EIF4A2-008	EIF4A2-009	EIF4A2-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF4A2-001 ENSP00000326381 ENST00000323963	Q14240 [Direct mapping] Eukaryotic initiation factor 4A-II Eukaryotic initiation factor 4A-II, N-terminally processed Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0003676 [nucleic acid binding] GO:0003743 [translation initiation factor activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010467 [gene expression] GO:0010501 [RNA secondary structure unwinding] GO:0016032 [viral process] GO:0016281 [eukaryotic translation initiation factor 4F complex] GO:0016887 [ATPase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048471 [perinuclear region of cytoplasm] GO:1900260 [negative regulation of RNA-directed RNA polymerase activity] Show all	407 aa 46.4 kDa	No	0
EIF4A2-004 ENSP00000398370 ENST00000440191	Q14240 [Direct mapping] Eukaryotic initiation factor 4A-II Eukaryotic initiation factor 4A-II, N-terminally processed Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0003676 [nucleic acid binding] GO:0003743 [translation initiation factor activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010467 [gene expression] GO:0010501 [RNA secondary structure unwinding] GO:0016032 [viral process] GO:0016281 [eukaryotic translation initiation factor 4F complex] GO:0016887 [ATPase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048471 [perinuclear region of cytoplasm] GO:1900260 [negative regulation of RNA-directed RNA polymerase activity] Show all	408 aa 46.5 kDa	No	0
EIF4A2-008 ENSP00000407504 ENST00000441007	C9JUF0 [Direct mapping] Eukaryotic initiation factor 4A-II Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010501 [RNA secondary structure unwinding] Show all	57 aa 6.3 kDa	No	0
EIF4A2-009 ENSP00000415878 ENST00000445596	E7EMV8 [Direct mapping] Eukaryotic initiation factor 4A-II Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010501 [RNA secondary structure unwinding] Show all	98 aa 10.7 kDa	No	0
EIF4A2-018 ENSP00000462571 ENST00000498746	J3KSN7 [Direct mapping] Eukaryotic initiation factor 4A-II Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010501 [RNA secondary structure unwinding] Show all	109 aa 12.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.