Expression of SST in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SST
Gene description	Somatostatin
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (ovarian cancer, pancreatic cancer)
HPA (cell line):	Group enriched (EFO-21, U-2 OS)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, duodenum, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in islets of Langerhans and enteroendocrine cells in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA019472 , CAB000075
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (ovarian cancer, pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019472	CAB000075

GENE INFORMATION
Gene name	SST (HGNC Symbol)
Synonyms	SMST
Description	Somatostatin (HGNC Symbol)
Entrez gene summary	The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.3
Chromosome location (bp)	187668906 - 187670399
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157005 (version 83.38)
Entrez gene	6750
UniProt	P61278 (UniProt - Evidence at protein level)
neXtProt	NX_P61278
Antibodypedia	SST antibodies

PROTEIN BROWSER

SST-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SST-001 ENSP00000287641 ENST00000287641	P61278 [Direct mapping] Somatostatin Somatostatin-28 Somatostatin-14 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006972 [hyperosmotic response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007268 [synaptic transmission] GO:0007584 [response to nutrient] GO:0007586 [digestion] GO:0008285 [negative regulation of cell proliferation] GO:0008628 [hormone-mediated apoptotic signaling pathway] GO:0009408 [response to heat] GO:0010243 [response to organonitrogen compound] GO:0010447 [response to acidic pH] GO:0030334 [regulation of cell migration] GO:0042493 [response to drug] GO:0043025 [neuronal cell body] GO:0043200 [response to amino acid] GO:0048545 [response to steroid hormone] Show all	116 aa 12.7 kDa	Yes	0