Cell atlas - SLC6A1 - The Human Protein Atlas

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SLC6A1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	SLC6A1
Gene description	Solute carrier family 6 (neurotransmitter transporter), member 1
Protein class	Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA013341
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA013341	A-431	Mitochondria
	HPA013341	U-2 OS	Mitochondria	Intensity
	HPA013341	U-251 MG	No staining

GENE INFORMATION
Gene name	SLC6A1 (HGNC Symbol)
Synonyms	GABATHG, GABATR, GAT1
Description	Solute carrier family 6 (neurotransmitter transporter), member 1 (HGNC Symbol)
Entrez gene summary	The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	10992724 - 11039247
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157103 (version 83.38)
Entrez gene	6529
UniProt	P30531 (UniProt - Evidence at protein level)
neXtProt	NX_P30531
Antibodypedia	SLC6A1 antibodies

PROTEIN BROWSER

SLC6A1-001	SLC6A1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A1-001 ENSP00000287766 ENST00000287766	P30531 [Direct mapping] Sodium- and chloride-dependent GABA transporter 1 A0A024R2G0 [Target identity:100%; Query identity:100%] Transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005332 [gamma-aminobutyric acid:sodium symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007612 [learning] GO:0009636 [response to toxic substance] GO:0009744 [response to sucrose] GO:0009986 [cell surface] GO:0010033 [response to organic substance] GO:0010243 [response to organonitrogen compound] GO:0010288 [response to lead ion] GO:0014054 [positive regulation of gamma-aminobutyric acid secretion] GO:0014070 [response to organic cyclic compound] GO:0014074 [response to purine-containing compound] GO:0015812 [gamma-aminobutyric acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0032355 [response to estradiol] GO:0042220 [response to cocaine] GO:0043005 [neuron projection] GO:0051260 [protein homooligomerization] GO:0051592 [response to calcium ion] GO:0051939 [gamma-aminobutyric acid import] GO:0055085 [transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	599 aa 67.1 kDa	No	>9
SLC6A1-002 ENSP00000411689 ENST00000425938	C9J5P8 [Direct mapping] Sodium- and chloride-dependent GABA transporter 1 Show all	Predicted intracellular proteins Show all		39 aa 4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.