Expression of SMG1 in cancer - Summary - The Human Protein Atlas

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SMG1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SMG1
Gene description	SMG1 phosphatidylinositol 3-kinase-related kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA006870 , HPA031623
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006870	HPA031623

GENE INFORMATION
Gene name	SMG1 (HGNC Symbol)
Synonyms	ATX, KIAA0421, LIP
Description	SMG1 phosphatidylinositol 3-kinase-related kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	18804853 - 18926454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157106 (version 83.38)
Entrez gene	23049
UniProt	Q96Q15 (UniProt - Evidence at protein level)
neXtProt	NX_Q96Q15
Antibodypedia	SMG1 antibodies

PROTEIN BROWSER

SMG1-001	SMG1-002	SMG1-003	SMG1-004	SMG1-005	SMG1-006	SMG1-013	SMG1-015	SMG1-017	SMG1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMG1-001 ENSP00000402515 ENST00000446231	Q96Q15 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000724 [double-strand break repair via homologous recombination] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006406 [mRNA export from nucleus] GO:0006950 [response to stress] GO:0010467 [gene expression] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0018105 [peptidyl-serine phosphorylation] GO:0044822 [poly(A) RNA binding] GO:0046777 [protein autophosphorylation] GO:0046854 [phosphatidylinositol phosphorylation] GO:0046872 [metal ion binding] GO:0046983 [protein dimerization activity] Show all	3661 aa 410.5 kDa	No	0
SMG1-002 ENSP00000432825 ENST00000532700	E9PNP6 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0005488 [binding] GO:0046983 [protein dimerization activity] Show all	335 aa 37.7 kDa	No	0
SMG1-003 ENSP00000458380 ENST00000565224	I3L0W2 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0005488 [binding] GO:0046983 [protein dimerization activity] Show all	607 aa 67.5 kDa	No	0
SMG1-004 ENSP00000460854 ENST00000561947	I3L400 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0005488 [binding] GO:0046983 [protein dimerization activity] Show all	551 aa 61.3 kDa	No	0
SMG1-005 ENSP00000456259 ENST00000565324	J3KRA9 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0046983 [protein dimerization activity] Show all	3551 aa 398.8 kDa	No	0
SMG1-006 ENSP00000455861 ENST00000563235	H3BQN7 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0005488 [binding] GO:0046983 [protein dimerization activity] Show all	853 aa 95.5 kDa	No	0
SMG1-013 ENSP00000455453 ENST00000569122	H3BPS6 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0046983 [protein dimerization activity] Show all	62 aa 7.5 kDa	No	0
SMG1-015 ENSP00000456025 ENST00000563836	H3BR09 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0046983 [protein dimerization activity] Show all	56 aa 6.2 kDa	No	0
SMG1-017 ENSP00000484278 ENST00000566328	A0A087X1K8 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0046983 [protein dimerization activity] Show all	85 aa 9 kDa	No	0
SMG1-201 ENSP00000481150 ENST00000330588	A0A087WXM7 [Direct mapping] Serine/threonine-protein kinase SMG1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0005488 [binding] GO:0046983 [protein dimerization activity] Show all	197 aa 22.5 kDa	No	0

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