Tissue expression of C8A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	C8A
Gene description	Complement component 8, alpha polypeptide
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	C8A
Synonyms
Description	Complement component 8, alpha polypeptide (HGNC Symbol)
Entrez gene summary	C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
Chromosome	1
Cytoband	p32.2
Chromosome location (bp)	56854806 - 56918221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157131 (version 83.38)
Entrez gene	731
UniProt	P07357 (UniProt - Evidence at protein level)
neXtProt	NX_P07357
Antibodypedia	C8A antibodies

PROTEIN BROWSER

C8A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C8A-001 ENSP00000354458 ENST00000361249	P07357 [Direct mapping] Complement component C8 alpha chain Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001848 [complement binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0006956 [complement activation] GO:0006957 [complement activation, alternative pathway] GO:0006958 [complement activation, classical pathway] GO:0016020 [membrane] GO:0019835 [cytolysis] GO:0030449 [regulation of complement activation] GO:0032403 [protein complex binding] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	584 aa 65.2 kDa	Yes	0