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TIMP4

GENERAL INFORMATION

Gene name

 TIMP4

Gene description

 TIMP metallopeptidase inhibitor 4

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (ASC TERT1, BEWO, NTERA-2, U-87 MG)
HPA (normal tissue):Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TIMP4

Synonyms

Description

 TIMP metallopeptidase inhibitor 4 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p25.2

Chromosome location (bp)

 12153051 - 12159351

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000157150 (version 83.38)

Entrez gene

 7079

UniProt

 Q99727 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q99727

Antibodypedia

 TIMP4 antibodies

PROTEIN BROWSER
TIMP4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TIMP4-001
ENSP00000287814
ENST00000287814
Q99727 [Direct mapping]
Metalloproteinase inhibitor 4
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
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GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007219 [Notch signaling pathway]
GO:0007417 [central nervous system development]
GO:0008150 [biological_process]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0009725 [response to hormone]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030017 [sarcomere]
GO:0032496 [response to lipopolysaccharide]
GO:0034097 [response to cytokine]
GO:0042493 [response to drug]
GO:0042698 [ovulation cycle]
GO:0043434 [response to peptide hormone]
GO:0046872 [metal ion binding]
GO:0048553 [negative regulation of metalloenzyme activity]
GO:0051045 [negative regulation of membrane protein ectodomain proteolysis]
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 224 aa
25.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.