Expression of CLEC18A in cancer - Summary - The Human Protein Atlas

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CLEC18A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLEC18A
Gene description	C-type lectin domain family 18, member A
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (renal cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (kidney, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, including renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA048976
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048976

GENE INFORMATION
Gene name	CLEC18A (HGNC Symbol)
Synonyms	MRCL
Description	C-type lectin domain family 18, member A (HGNC Symbol)
Entrez gene summary	This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	69950705 - 69964452
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157322 (version 83.38)
Entrez gene	348174
UniProt	A5D8T8 (UniProt - Evidence at protein level)
neXtProt	NX_A5D8T8
Antibodypedia	CLEC18A antibodies

PROTEIN BROWSER

CLEC18A-001	CLEC18A-002	CLEC18A-003	CLEC18A-007	CLEC18A-201	CLEC18A-202	CLEC18A-203	CLEC18A-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC18A-001 ENSP00000288040 ENST00000288040	A5D8T8 [Direct mapping] C-type lectin domain family 18 member A Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0030247 [polysaccharide binding] Show all	446 aa 49.6 kDa	Yes	0
CLEC18A-002 ENSP00000377304 ENST00000393701	A5D8T8 [Direct mapping] C-type lectin domain family 18 member A Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0030247 [polysaccharide binding] Show all	446 aa 49.6 kDa	Yes	0
CLEC18A-003 ENSP00000454685 ENST00000568461	A5D8T8 [Direct mapping] C-type lectin domain family 18 member A Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0030247 [polysaccharide binding] Show all	446 aa 49.6 kDa	Yes	0
CLEC18A-007 ENSP00000454976 ENST00000561889	H3BNR9 [Direct mapping] C-type lectin domain family 18 member A Show all	Phobius predicted secreted proteins Predicted intracellular proteins Show all		66 aa 7.1 kDa	No	0
CLEC18A-201 ENSP00000413990 ENST00000449317	F8W692 [Direct mapping] C-type lectin domain family 18 member A Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	455 aa 50.5 kDa	Yes	0
CLEC18A-202 ENSP00000484176 ENST00000615430	A5D8T8 [Direct mapping] C-type lectin domain family 18 member A Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0030247 [polysaccharide binding] Show all	446 aa 49.6 kDa	Yes	0
CLEC18A-203 ENSP00000478435 ENST00000617654	A0A087WU79 [Direct mapping] C-type lectin domain family 18 member A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	299 aa 32.8 kDa	Yes	0
CLEC18A-204 ENSP00000483531 ENST00000620064	A0A087X0N6 [Direct mapping] C-type lectin domain family 18 member A Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	303 aa 33.1 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.