Tissue expression of DDX19B - Summary - The Human Protein Atlas

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DDX19B

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DDX19B
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic and nuclear membrane expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 3 antibodies. HPA046380 , CAB037229 , CAB037284
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DDX19B (HGNC Symbol)
Synonyms	DBP5, DDX19
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	70289663 - 70335283
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157349 (version 83.38)
Entrez gene	11269
UniProt	Q9UMR2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UMR2
Antibodypedia	DDX19B antibodies

PROTEIN BROWSER

DDX19B-001	DDX19B-004	DDX19B-005	DDX19B-006	DDX19B-007	DDX19B-009	DDX19B-011	DDX19B-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX19B-001 ENSP00000288071 ENST00000288071	Q9UMR2 [Direct mapping] ATP-dependent RNA helicase DDX19B Show all	Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	479 aa 53.9 kDa	No	0
DDX19B-004 ENSP00000348271 ENST00000355992	Q9UMR2 [Direct mapping] ATP-dependent RNA helicase DDX19B Show all	Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	448 aa 50.5 kDa	No	0
DDX19B-005 ENSP00000456574 ENST00000563392	Q9UMR2 [Direct mapping] ATP-dependent RNA helicase DDX19B A0A024QZ90 [Target identity:100%; Query identity:100%] HCG1998531, isoform CRA_c Show all	Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	370 aa 41.8 kDa	No	0
DDX19B-006 ENSP00000392639 ENST00000451014	Q9UMR2 [Direct mapping] ATP-dependent RNA helicase DDX19B Show all	Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	453 aa 51.1 kDa	No	0
DDX19B-007 ENSP00000456757 ENST00000568625	Q9UMR2 [Direct mapping] ATP-dependent RNA helicase DDX19B A0A024QZ90 [Target identity:100%; Query identity:100%] HCG1998531, isoform CRA_c Show all	Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	370 aa 41.8 kDa	No	0
DDX19B-009 ENSP00000377267 ENST00000393657	Q9UMR2 [Direct mapping] ATP-dependent RNA helicase DDX19B A0A024QZ90 [Target identity:100%; Query identity:100%] HCG1998531, isoform CRA_c Show all	Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0070062 [extracellular exosome] Show all	370 aa 41.8 kDa	No	0
DDX19B-011 ENSP00000455813 ENST00000563206	H3BQK0 [Direct mapping] ATP-dependent RNA helicase DDX19B; HCG1998531, isoform CRA_g Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	484 aa 54.5 kDa	No	0
DDX19B-013 ENSP00000454495 ENST00000566216	H3BMQ5 [Direct mapping] ATP-dependent RNA helicase DDX19B Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	233 aa 26.1 kDa	No	0

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The Human Protein Atlas

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