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Moderate cytoplasmic positivity was observed in most cancer tissues. A few cases of thyroid cancers and malignant melanomas were strongly immunoreactive. Skin cancers and lymphomas were weakly stained or generally negative.
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]