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Most malignant cells exhibited weak to moderate cytoplasmic and nuclear positivity. A few squamous cell carcinomas of cervical cancer showed strong positivity. Malignant lymphomas, carcinoids, testis, liver and lung cancers were mainly negative.
GENE INFORMATION
Gene name
FUK (HGNC Symbol)
Synonyms
FLJ39408
Description
Fucokinase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]