Cell atlas - ARSE - The Human Protein Atlas

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ARSE

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	ARSE
Gene description	Arylsulfatase E (chondrodysplasia punctata 1)
Protein class	Disease related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (A549, Hep G2, CACO-2, NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA060518
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, Hep G2, CACO-2, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA060518	A549	No staining
	HPA060518	Hep G2	Golgi apparatus
	HPA060518	U-2 OS	No staining

GENE INFORMATION
Gene name	ARSE (HGNC Symbol)
Synonyms	CDPX, CDPX1
Description	Arylsulfatase E (chondrodysplasia punctata 1) (HGNC Symbol)
Entrez gene summary	Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	2934632 - 2968310
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157399 (version 83.38)
Entrez gene	415
UniProt	P51690 (UniProt - Evidence at protein level)
neXtProt	NX_P51690
Antibodypedia	ARSE antibodies

PROTEIN BROWSER

ARSE-001	ARSE-002	ARSE-201	ARSE-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARSE-001 ENSP00000370526 ENST00000381134	P51690 [Direct mapping] Arylsulfatase E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005795 [Golgi stack] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	589 aa 65.7 kDa	Yes	2
ARSE-002 ENSP00000406528 ENST00000438544	C9J5G7 [Direct mapping] Arylsulfatase E Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	178 aa 19.3 kDa	Yes	0
ARSE-201 ENSP00000438198 ENST00000540563	F5H324 [Direct mapping] Arylsulfatase E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0016021 [integral component of membrane] Show all	544 aa 61.1 kDa	No	2
ARSE-202 ENSP00000441417 ENST00000545496	F5GYY5 [Direct mapping] Arylsulfatase E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0016021 [integral component of membrane] Show all	614 aa 68.2 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.