Expression of AASDH in cancer - Summary - The Human Protein Atlas

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AASDH

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AASDH
Gene description	Aminoadipate-semialdehyde dehydrogenase
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA036472 , HPA036473
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036472	HPA036473

GENE INFORMATION
Gene name	AASDH (HGNC Symbol)
Synonyms	ACSF4, LYS2, NRPS998
Description	Aminoadipate-semialdehyde dehydrogenase (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q12
Chromosome location (bp)	56338287 - 56387508
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157426 (version 83.38)
Entrez gene	132949
UniProt	Q4L235 (UniProt - Evidence at protein level)
neXtProt	NX_Q4L235
Antibodypedia	AASDH antibodies

PROTEIN BROWSER

AASDH-001	AASDH-002	AASDH-006	AASDH-201	AASDH-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AASDH-001 ENSP00000205214 ENST00000205214	Q4L235 [Direct mapping] Acyl-CoA synthetase family member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] Show all	1098 aa 122.6 kDa	No	1
AASDH-002 ENSP00000423760 ENST00000513376	Q4L235 [Direct mapping] Acyl-CoA synthetase family member 4 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] Show all	998 aa 111.4 kDa	No	0
AASDH-006 ENSP00000421171 ENST00000502617	Q4L235 [Direct mapping] Acyl-CoA synthetase family member 4 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] Show all	841 aa 94.3 kDa	No	0
AASDH-201 ENSP00000409656 ENST00000451613	Q4L235 [Direct mapping] Acyl-CoA synthetase family member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] Show all	857 aa 96.2 kDa	No	2
AASDH-202 ENSP00000473564 ENST00000602986	R4GNB1 [Direct mapping] Acyl-CoA synthetase family member 4 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	945 aa 104.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.