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DYRK1A

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GENERAL INFORMATION

Gene name

 DYRK1A

Gene description

 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA015323 , HPA015810
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoli (fibrillar center).

Main location

 Cytosol (approved)

Additional location

 Nucleoli fibrillar center (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA015323 A-431 Cytosol
HPA015323 U-2 OS Nucleoli fibrillar center
Cytosol
HPA015323 U-251 MG Cytosol
HPA015810 A-431 Cytosol
HPA015810 U-2 OS No staining    
HPA015810 U-251 MG Cytosol

GENE INFORMATION

Gene name

 DYRK1A (HGNC Symbol)

Synonyms

 DYRK, DYRK1, MNBH

Description

 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.13

Chromosome location (bp)

 37365790 - 37517450

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157540 (version 83.38)

Entrez gene

 1859

UniProt

 Q13627 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13627

Antibodypedia

 DYRK1A antibodies

PROTEIN BROWSER
DYRK1A-001
DYRK1A-003
DYRK1A-004
DYRK1A-005
DYRK1A-006
DYRK1A-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DYRK1A-001
ENSP00000342690
ENST00000338785
Q13627 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0007623 [circadian rhythm]
GO:0016607 [nuclear speck]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043621 [protein self-association]
GO:0046777 [protein autophosphorylation]
GO:0048156 [tau protein binding]
GO:0090312 [positive regulation of protein deacetylation]
Show all
 584 aa
66.1 kDa 		No 0
DYRK1A-003
ENSP00000340373
ENST00000339659
Q13627 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0007623 [circadian rhythm]
GO:0016607 [nuclear speck]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043621 [protein self-association]
GO:0046777 [protein autophosphorylation]
GO:0048156 [tau protein binding]
GO:0090312 [positive regulation of protein deacetylation]
Show all
 754 aa
84.6 kDa 		No 0
DYRK1A-004
ENSP00000398483
ENST00000455097
Q76N25 [Direct mapping]
Dual-specificity tyrosine-phosphorylation-regulated kinase 1A; MNB/DYRK protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
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 46 aa
5 kDa 		No 0
DYRK1A-005
ENSP00000412269
ENST00000426672
E7EMI5 [Direct mapping]
Dual-specificity tyrosine-phosphorylation-regulated kinase 1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0046777 [protein autophosphorylation]
Show all
 131 aa
14.9 kDa 		No 0
DYRK1A-006
ENSP00000381932
ENST00000398960
Q13627 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0007623 [circadian rhythm]
GO:0016607 [nuclear speck]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030529 [ribonucleoprotein complex]
GO:0042802 [identical protein binding]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043621 [protein self-association]
GO:0046777 [protein autophosphorylation]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0048156 [tau protein binding]
GO:0090312 [positive regulation of protein deacetylation]
Show all
 763 aa
85.6 kDa 		No 0
DYRK1A-008
ENSP00000381929
ENST00000398956
Q13627 [Direct mapping]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0007623 [circadian rhythm]
GO:0016607 [nuclear speck]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043621 [protein self-association]
GO:0046777 [protein autophosphorylation]
GO:0048156 [tau protein binding]
GO:0090312 [positive regulation of protein deacetylation]
Show all
 529 aa
60.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.