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ERG

GENERAL INFORMATION

Gene name

 ERG

Gene description

 V-ets avian erythroblastosis virus E26 oncogene homolog

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HUVEC TERT2, MOLT-4, REH, TIME)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA046598 , CAB018377
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and renal cancer (unfavourable).
Cervical cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046598
CAB018377

GENE INFORMATION

Gene name

 ERG (HGNC Symbol)

Synonyms

 erg-3, p55

Description

 V-ets avian erythroblastosis virus E26 oncogene homolog (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

Chromosome

 21

Cytoband

 q22.2

Chromosome location (bp)

 38380027 - 38661780

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157554 (version 83.38)

Entrez gene

 2078

UniProt

 P11308 (UniProt - Evidence at protein level)

neXtProt

 NX_P11308

Antibodypedia

 ERG antibodies

PROTEIN BROWSER
«
ERG-001
ERG-002
ERG-004
ERG-005
ERG-007
ERG-008
ERG-009
ERG-013
ERG-014
ERG-201
ERG-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERG-001
ENSP00000288319
ENST00000288319
P11308 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0030529 [ribonucleoprotein complex]
GO:0043565 [sequence-specific DNA binding]
Show all
 479 aa
53.8 kDa 		No 0
ERG-002
ENSP00000414150
ENST00000417133
P11308 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003197 [endocardial cushion development]
GO:0003199 [endocardial cushion to mesenchymal transition involved in heart valve formation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0030529 [ribonucleoprotein complex]
GO:0043565 [sequence-specific DNA binding]
GO:2000504 [positive regulation of blood vessel remodeling]
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 486 aa
54.6 kDa 		No 0
ERG-004
ENSP00000381871
ENST00000398897
P11308 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0030529 [ribonucleoprotein complex]
GO:0043565 [sequence-specific DNA binding]
Show all
 363 aa
41.4 kDa 		No 0
ERG-005
ENSP00000381877
ENST00000398905
B5MDW0 [Direct mapping]
Erythroblast transformation-specific transcription factor ERG variant 10; Transcriptional regulator ERG
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 455 aa
51.3 kDa 		No 0
ERG-007
ENSP00000381882
ENST00000398911
P11308 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0030529 [ribonucleoprotein complex]
GO:0043565 [sequence-specific DNA binding]
Show all
 462 aa
52 kDa 		No 0
ERG-008
ENSP00000381881
ENST00000398910
A8MZ24 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 463 aa
52 kDa 		No 0
ERG-009
ENSP00000381879
ENST00000398907
A8MX39 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 456 aa
51.2 kDa 		No 0
ERG-013
ENSP00000381891
ENST00000398919
P11308 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0030529 [ribonucleoprotein complex]
GO:0043565 [sequence-specific DNA binding]
Show all
 486 aa
54.6 kDa 		No 0
ERG-014
ENSP00000396268
ENST00000453032
A0A0C4DG41 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 387 aa
44 kDa 		No 0
ERG-201
ENSP00000415659
ENST00000429727
A0A088AWP2 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 220 aa
24.8 kDa 		No 0
ERG-202
ENSP00000394694
ENST00000442448
P11308 [Direct mapping]
Transcriptional regulator ERG
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0030529 [ribonucleoprotein complex]
GO:0043565 [sequence-specific DNA binding]
Show all
 462 aa
52 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.