Expression of SLC35B2 in cancer - Summary - The Human Protein Atlas

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SLC35B2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC35B2
Gene description	Solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA029638
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), prostate cancer (favourable) and breast cancer (unfavourable).
Liver cancer p<0.001 Prostate cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029638

GENE INFORMATION
Gene name	SLC35B2 (HGNC Symbol)
Synonyms	UGTrel4
Description	Solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 (HGNC Symbol)
Entrez gene summary	Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	44254096 - 44257890
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157593 (version 83.38)
Entrez gene	347734
UniProt	Q8TB61 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TB61
Antibodypedia	SLC35B2 antibodies

PROTEIN BROWSER

SLC35B2-002	SLC35B2-003	SLC35B2-201	SLC35B2-202	SLC35B2-203	SLC35B2-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35B2-002 ENSP00000377401 ENST00000393812	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	432 aa 47.5 kDa	Yes	>9
SLC35B2-003 ENSP00000377399 ENST00000393810	A0A0A0MS46 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	94 aa 10.4 kDa	Yes	1
SLC35B2-201 ENSP00000440340 ENST00000537814	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	299 aa 32.7 kDa	No	8
SLC35B2-202 ENSP00000443845 ENST00000538577	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	339 aa 37.2 kDa	Yes	8
SLC35B2-203 ENSP00000480681 ENST00000615337	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	383 aa 42.1 kDa	No	8
SLC35B2-204 ENSP00000483181 ENST00000619636	Q8TB61 [Direct mapping] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044281 [small molecule metabolic process] GO:0046963 [3'-phosphoadenosine 5'-phosphosulfate transport] GO:0046964 [3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0055085 [transmembrane transport] GO:1902559 [3'-phospho-5'-adenylyl sulfate transmembrane transport] Show all	383 aa 42.1 kDa	No	8

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