Expression of CREB3L1 in cancer - Summary

GENERAL INFORMATION
Gene name	CREB3L1
Gene description	CAMP responsive element binding protein 3-like 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins Transcription factors
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+, BJ hTERT+ SV40 Large T+)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues. Distinct expression in exocrine pancreas.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA024069 , CAB026151
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA024069	CAB026151

GENE INFORMATION
Gene name	CREB3L1 (HGNC Symbol)
Synonyms	OASIS
Description	CAMP responsive element binding protein 3-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	46277661 - 46321422
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157613 (version 83.38)
Entrez gene	90993
UniProt	Q96BA8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BA8
Antibodypedia	CREB3L1 antibodies

PROTEIN BROWSER

CREB3L1-001	CREB3L1-003	CREB3L1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CREB3L1-001 ENSP00000481956 ENST00000621158	Q96BA8 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 1 Processed cyclic AMP-responsive element-binding protein 3-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001649 [osteoblast differentiation] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0070278 [extracellular matrix constituent secretion] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] Show all	519 aa 57 kDa	No	1
CREB3L1-003 ENSP00000431677 ENST00000534787	E9PK33 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	106 aa 11.3 kDa	No	0
CREB3L1-005 ENSP00000436574 ENST00000530518	H0YEU7 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	123 aa 13.9 kDa	No	0