Expression of SLC34A2 in cancer - Summary - The Human Protein Atlas

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SLC34A2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC34A2
Gene description	Solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Protein class	Cancer-related genes Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Group enriched (BEWO, EFO-21, RPTEC TERT1)
HPA (normal tissue):	Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in lung type II pneumocytes and female genital tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA037989
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037989

GENE INFORMATION
Gene name	SLC34A2 (HGNC Symbol)
Synonyms	NAPI-3B
Description	Solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	4
Cytoband	p15.2
Chromosome location (bp)	25655301 - 25678748
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157765 (version 83.38)
Entrez gene	10568
UniProt	O95436 (UniProt - Evidence at protein level)
neXtProt	NX_O95436
Antibodypedia	SLC34A2 antibodies

PROTEIN BROWSER

SLC34A2-001	SLC34A2-002	SLC34A2-003	SLC34A2-005	SLC34A2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC34A2-001 ENSP00000371483 ENST00000382051	O95436 [Direct mapping] Sodium-dependent phosphate transport protein 2B Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0005436 [sodium:phosphate symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0006811 [ion transport] GO:0006817 [phosphate ion transport] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030643 [cellular phosphate ion homeostasis] GO:0031402 [sodium ion binding] GO:0031526 [brush border membrane] GO:0031982 [vesicle] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042301 [phosphate ion binding] GO:0043627 [response to estrogen] GO:0044267 [cellular protein metabolic process] GO:0044341 [sodium-dependent phosphate transport] GO:0055085 [transmembrane transport] Show all	690 aa 75.8 kDa	No	9
SLC34A2-002 ENSP00000425501 ENST00000504570	O95436 [Direct mapping] Sodium-dependent phosphate transport protein 2B Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005436 [sodium:phosphate symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006817 [phosphate ion transport] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030643 [cellular phosphate ion homeostasis] GO:0031402 [sodium ion binding] GO:0031526 [brush border membrane] GO:0031982 [vesicle] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042301 [phosphate ion binding] GO:0043627 [response to estrogen] GO:0044267 [cellular protein metabolic process] GO:0044341 [sodium-dependent phosphate transport] GO:0055085 [transmembrane transport] Show all	689 aa 75.7 kDa	No	9
SLC34A2-003 ENSP00000423021 ENST00000503434	O95436 [Direct mapping] Sodium-dependent phosphate transport protein 2B Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005436 [sodium:phosphate symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006817 [phosphate ion transport] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030643 [cellular phosphate ion homeostasis] GO:0031402 [sodium ion binding] GO:0031526 [brush border membrane] GO:0031982 [vesicle] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042301 [phosphate ion binding] GO:0043627 [response to estrogen] GO:0044267 [cellular protein metabolic process] GO:0044341 [sodium-dependent phosphate transport] GO:0055085 [transmembrane transport] Show all	689 aa 75.7 kDa	No	9
SLC34A2-005 ENSP00000423038 ENST00000513204	D6RA94 [Direct mapping] Sodium-dependent phosphate transport protein 2B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044341 [sodium-dependent phosphate transport] Show all	163 aa 17.6 kDa	No	2
SLC34A2-006 ENSP00000424266 ENST00000507530	D6RBC0 [Direct mapping] Sodium-dependent phosphate transport protein 2B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044341 [sodium-dependent phosphate transport] Show all	161 aa 17.5 kDa	No	2

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