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AP3S2

GENERAL INFORMATION

Gene name

 AP3S2

Gene description

 Adaptor-related protein complex 3, sigma 2 subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA049270
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049270

GENE INFORMATION

Gene name

 AP3S2 (HGNC Symbol)

Synonyms

 sigma3b

Description

 Adaptor-related protein complex 3, sigma 2 subunit (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 89830599 - 89894638

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000157823 (version 83.38)

Entrez gene

 10239

UniProt

 P59780 (UniProt - Evidence at transcript level)

neXtProt

 NX_P59780

Antibodypedia

 AP3S2 antibodies

PROTEIN BROWSER
AP3S2-001
AP3S2-009
AP3S2-014
AP3S2-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP3S2-001
ENSP00000338777
ENST00000336418
P59780 [Direct mapping]
AP-3 complex subunit sigma-2
A0A024RC62 [Target identity:100%; Query identity:100%]
Adaptor-related protein complex 3, sigma 2 subunit, isoform CRA_a
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Predicted intracellular proteins
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GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008089 [anterograde axon cargo transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030123 [AP-3 adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0048490 [anterograde synaptic vesicle transport]
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 193 aa
22 kDa 		No 0
AP3S2-009
ENSP00000453223
ENST00000558011
H0YLI7 [Direct mapping]
AP-3 complex subunit sigma-2; Adaptor-related protein complex 3, sigma 2 subunit, isoform CRA_d
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   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
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GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
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 205 aa
23.4 kDa 		No 0
AP3S2-014
ENSP00000453852
ENST00000560940
H0YN38 [Direct mapping]
AP-3 complex subunit sigma-2
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Predicted intracellular proteins
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GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
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 156 aa
18.2 kDa 		No 0
AP3S2-017
ENSP00000481434
ENST00000617003
A0A087WY05 [Direct mapping]
AP-3 complex subunit sigma-2
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Predicted intracellular proteins
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GO:0006810 [transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
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 63 aa
7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.