Expression of DRC1 in cancer - Summary - The Human Protein Atlas

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DRC1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	DRC1
Gene description	Dynein regulatory complex subunit 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	DRC1 (HGNC Symbol)
Synonyms	C2orf39, CCDC164, CILD21, FLJ32660, MGC16372
Description	Dynein regulatory complex subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	26401916 - 26456711
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157856 (version 83.38)
Entrez gene	92749
UniProt	Q96MC2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96MC2
Antibodypedia	DRC1 antibodies

PROTEIN BROWSER

DRC1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DRC1-001 ENSP00000288710 ENST00000288710	Q96MC2 [Direct mapping] Dynein regulatory complex protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005856 [cytoskeleton] GO:0005930 [axoneme] GO:0007368 [determination of left/right symmetry] GO:0007507 [heart development] GO:0060285 [cilium-dependent cell motility] GO:0070286 [axonemal dynein complex assembly] GO:0071973 [bacterial-type flagellum-dependent cell motility] Show all	740 aa 87.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.