Expression of C12orf43 in cancer - Summary - The Human Protein Atlas

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C12orf43

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C12orf43
Gene description	Chromosome 12 open reading frame 43
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Sub cellular location is contradicted by external data.
Reliability score	Uncertain based on 1 antibody. HPA046148
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046148

GENE INFORMATION
Gene name	C12orf43 (HGNC Symbol)
Synonyms	FLJ12448
Description	Chromosome 12 open reading frame 43 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	121000486 - 121016502
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157895 (version 83.38)
Entrez gene	64897
UniProt	Q96C57 (UniProt - Evidence at protein level)
neXtProt	NX_Q96C57
Antibodypedia	C12orf43 antibodies

PROTEIN BROWSER

C12orf43-001	C12orf43-002	C12orf43-005	C12orf43-006	C12orf43-008	C12orf43-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C12orf43-001 ENSP00000288757 ENST00000288757	Q96C57 [Direct mapping] Uncharacterized protein C12orf43 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		262 aa 28.2 kDa	No	0
C12orf43-002 ENSP00000442224 ENST00000537817	F5H7W8 [Direct mapping] Chromosome 12 open reading frame 43, isoform CRA_a; Uncharacterized protein C12orf43 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		293 aa 31.7 kDa	No	0
C12orf43-005 ENSP00000437803 ENST00000539736	G5EA44 [Direct mapping] Chromosome 12 open reading frame 43, isoform CRA_b; Uncharacterized protein C12orf43 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		252 aa 27 kDa	No	0
C12orf43-006 ENSP00000438856 ENST00000535367	F5H3K2 [Direct mapping] Uncharacterized protein C12orf43 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 20.5 kDa	No	0
C12orf43-008 ENSP00000442041 ENST00000538296	F5H8B7 [Direct mapping] Uncharacterized protein C12orf43 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		195 aa 21.1 kDa	No	0
C12orf43-201 ENSP00000409788 ENST00000445832	E7ENF1 [Direct mapping] Uncharacterized protein C12orf43 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		221 aa 23.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.