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PEX10

GENERAL INFORMATION

Gene name

 PEX10

Gene description

 Peroxisomal biogenesis factor 10

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA049755
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PEX10 (HGNC Symbol)

Synonyms

 RNF69

Description

 Peroxisomal biogenesis factor 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.32

Chromosome location (bp)

 2403964 - 2413797

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157911 (version 83.38)

Entrez gene

 5192

UniProt

 O60683 (UniProt - Evidence at protein level)

neXtProt

 NX_O60683

Antibodypedia

 PEX10 antibodies

PROTEIN BROWSER
PEX10-001
PEX10-002
PEX10-003
PEX10-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PEX10-001
ENSP00000288774
ENST00000288774
O60683 [Direct mapping]
Peroxisome biogenesis factor 10
A0A024R0A4 [Target identity:100%; Query identity:100%]
Peroxisome biogenesis factor 10, isoform CRA_b
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005779 [integral component of peroxisomal membrane]
GO:0007031 [peroxisome organization]
GO:0008022 [protein C-terminus binding]
GO:0008270 [zinc ion binding]
GO:0016558 [protein import into peroxisome matrix]
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 346 aa
39.2 kDa 		No 2
PEX10-002
ENSP00000407922
ENST00000447513
O60683 [Direct mapping]
Peroxisome biogenesis factor 10
A0A024R068 [Target identity:100%; Query identity:100%]
Peroxisome biogenesis factor 10, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005779 [integral component of peroxisomal membrane]
GO:0007031 [peroxisome organization]
GO:0008022 [protein C-terminus binding]
GO:0008270 [zinc ion binding]
GO:0016558 [protein import into peroxisome matrix]
Show all
 326 aa
37.1 kDa 		No 2
PEX10-003
ENSP00000424291
ENST00000507596
D6RBB0 [Direct mapping]
Peroxisome biogenesis factor 10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005779 [integral component of peroxisomal membrane]
GO:0008270 [zinc ion binding]
GO:0016558 [protein import into peroxisome matrix]
Show all
 324 aa
36.9 kDa 		No 2
PEX10-004
ENSP00000464289
ENST00000508384
J3QRM4 [Direct mapping]
Peroxisome biogenesis factor 10
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 30 aa
3.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.