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BRE

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GENERAL INFORMATION

Gene name

 BRE

Gene description

 Brain and reproductive organ-expressed (TNFRSF1A modulator)

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA017926
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA017926 A-431 Cytosol
HPA017926 U-2 OS Cytosol
HPA017926 U-251 MG No staining    

GENE INFORMATION

Gene name

 BRE (HGNC Symbol)

Synonyms

 BRCC4, BRCC45

Description

 Brain and reproductive organ-expressed (TNFRSF1A modulator) (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 p23.2

Chromosome location (bp)

 27889941 - 28338901

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158019 (version 83.38)

Entrez gene

 9577

UniProt

 Q9NXR7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NXR7

Antibodypedia

 BRE antibodies

PROTEIN BROWSER
BRE-001
BRE-002
BRE-003
BRE-004
BRE-005
BRE-006
BRE-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRE-001
ENSP00000343412
ENST00000344773
Q9NXR7 [Direct mapping]
BRCA1-A complex subunit BRE
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000268 [peroxisome targeting sequence binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0010212 [response to ionizing radiation]
GO:0016568 [chromatin modification]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0070531 [BRCA1-A complex]
GO:0070552 [BRISC complex]
Show all
 415 aa
47 kDa 		No 0
BRE-002
ENSP00000368953
ENST00000379632
Q9NXR7 [Direct mapping]
BRCA1-A complex subunit BRE
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000268 [peroxisome targeting sequence binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0010212 [response to ionizing radiation]
GO:0016568 [chromatin modification]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0070531 [BRCA1-A complex]
GO:0070552 [BRISC complex]
Show all
 376 aa
42.7 kDa 		No 0
BRE-003
ENSP00000368945
ENST00000379624
Q9NXR7 [Direct mapping]
BRCA1-A complex subunit BRE
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000268 [peroxisome targeting sequence binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0010212 [response to ionizing radiation]
GO:0016568 [chromatin modification]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0070531 [BRCA1-A complex]
GO:0070552 [BRISC complex]
Show all
 383 aa
43.6 kDa 		No 0
BRE-004
ENSP00000339371
ENST00000342045
Q9NXR7 [Direct mapping]
BRCA1-A complex subunit BRE
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000268 [peroxisome targeting sequence binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0010212 [response to ionizing radiation]
GO:0016568 [chromatin modification]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0070531 [BRCA1-A complex]
GO:0070552 [BRISC complex]
Show all
 383 aa
43.6 kDa 		No 0
BRE-005
ENSP00000354699
ENST00000361704
Q9NXR7 [Direct mapping]
BRCA1-A complex subunit BRE
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000152 [nuclear ubiquitin ligase complex]
GO:0000268 [peroxisome targeting sequence binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0010212 [response to ionizing radiation]
GO:0016568 [chromatin modification]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031593 [polyubiquitin binding]
GO:0045739 [positive regulation of DNA repair]
GO:0070531 [BRCA1-A complex]
GO:0070552 [BRISC complex]
Show all
 376 aa
42.7 kDa 		No 0
BRE-006
ENSP00000392345
ENST00000436924
C9J2G0 [Direct mapping]
BRCA1-A complex subunit BRE
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 153 aa
17.3 kDa 		No 0
BRE-009
ENSP00000368950
ENST00000379629
F8W733 [Direct mapping]
BRCA1-A complex subunit BRE
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 284 aa
32 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.