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TRIM63

GENERAL INFORMATION

Gene name

 TRIM63

Gene description

 Tripartite motif containing 63, E3 ubiquitin protein ligase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enriched (SK-MEL-30)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TRIM63 (HGNC Symbol)

Synonyms

 IRF, MURF-1, RNF28, SMRZ

Description

 Tripartite motif containing 63, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 26051304 - 26068436

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158022 (version 83.38)

Entrez gene

 84676

UniProt

 Q969Q1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969Q1

Antibodypedia

 TRIM63 antibodies

PROTEIN BROWSER
TRIM63-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM63-001
ENSP00000363390
ENST00000374272
Q969Q1 [Direct mapping]
E3 ubiquitin-protein ligase TRIM63
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010468 [regulation of gene expression]
GO:0014732 [skeletal muscle atrophy]
GO:0014878 [response to electrical stimulus involved in regulation of muscle adaptation]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030018 [Z disc]
GO:0031430 [M band]
GO:0031432 [titin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043292 [contractile fiber]
GO:0051384 [response to glucocorticoid]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070555 [response to interleukin-1]
GO:0071549 [cellular response to dexamethasone stimulus]
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 353 aa
40.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.