Cell atlas - GRHL3 - The Human Protein Atlas

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GRHL3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GRHL3
Gene description	Grainyhead-like transcription factor 3
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins Transcription factors
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Group enriched (RT4, BEWO, MCF7, HaCaT, hTCEpi)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059960
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RT4, BEWO, MCF7, HaCaT, hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059960	MCF7	Nucleoplasm
	HPA059960	RT4	Nucleoplasm
	HPA059960	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	GRHL3 (HGNC Symbol)
Synonyms	SOM, TFCP2L4
Description	Grainyhead-like transcription factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	24319322 - 24364482
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158055 (version 83.38)
Entrez gene	57822
UniProt	Q8TE85 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TE85
Antibodypedia	GRHL3 antibodies

PROTEIN BROWSER

GRHL3-001	GRHL3-002	GRHL3-003	GRHL3-005	GRHL3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRHL3-001 ENSP00000348333 ENST00000356046	Q8TE85 [Direct mapping] Grainyhead-like protein 3 homolog Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001843 [neural tube closure] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008544 [epidermis development] GO:0031490 [chromatin DNA binding] GO:0032956 [regulation of actin cytoskeleton organization] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	556 aa 62.4 kDa	No	0
GRHL3-002 ENSP00000288955 ENST00000350501	Q8TE85 [Direct mapping] Grainyhead-like protein 3 homolog Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001736 [establishment of planar polarity] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007389 [pattern specification process] GO:0007398 [ectoderm development] GO:0007417 [central nervous system development] GO:0008544 [epidermis development] GO:0010628 [positive regulation of gene expression] GO:0031490 [chromatin DNA binding] GO:0032956 [regulation of actin cytoskeleton organization] GO:0042060 [wound healing] GO:0043547 [positive regulation of GTPase activity] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0061029 [eyelid development in camera-type eye] GO:0061436 [establishment of skin barrier] GO:0090103 [cochlea morphogenesis] GO:0090179 [planar cell polarity pathway involved in neural tube closure] Show all	626 aa 70.3 kDa	No	0
GRHL3-003 ENSP00000236255 ENST00000236255	Q8TE85 [Direct mapping] Grainyhead-like protein 3 homolog Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001843 [neural tube closure] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008544 [epidermis development] GO:0031490 [chromatin DNA binding] GO:0032956 [regulation of actin cytoskeleton organization] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	607 aa 68.4 kDa	Yes	0
GRHL3-005 ENSP00000354943 ENST00000361548	Q8TE85 [Direct mapping] Grainyhead-like protein 3 homolog Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001843 [neural tube closure] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008544 [epidermis development] GO:0031490 [chromatin DNA binding] GO:0032956 [regulation of actin cytoskeleton organization] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	602 aa 67.7 kDa	No	0
GRHL3-008 ENSP00000431290 ENST00000524724	E9PLT6 [Direct mapping] Grainyhead-like protein 3 homolog Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] Show all	81 aa 9.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.