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NCK1

GENERAL INFORMATION

Gene name

 NCK1

Gene description

 NCK adaptor protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, often with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB005063
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB005063

GENE INFORMATION

Gene name

 NCK1 (HGNC Symbol)

Synonyms

 NCK, NCKalpha

Description

 NCK adaptor protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

Chromosome

 3

Cytoband

 q22.3

Chromosome location (bp)

 136862208 - 136949823

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158092 (version 83.38)

Entrez gene

 4690

UniProt

 P16333 (UniProt - Evidence at protein level)

neXtProt

 NX_P16333

Antibodypedia

 NCK1 antibodies

PROTEIN BROWSER
NCK1-001
NCK1-002
NCK1-003
NCK1-004
NCK1-005
NCK1-006
NCK1-009
NCK1-010
NCK1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCK1-001
ENSP00000288986
ENST00000288986
P16333 [Direct mapping]
Cytoplasmic protein NCK1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005886 [plasma membrane]
GO:0007172 [signal complex assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008093 [cytoskeletal adaptor activity]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030674 [protein binding, bridging]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030971 [receptor tyrosine kinase binding]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042110 [T cell activation]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0060548 [negative regulation of cell death]
GO:0070262 [peptidyl-serine dephosphorylation]
GO:0071074 [eukaryotic initiation factor eIF2 binding]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903676 [positive regulation of cap-dependent translational initiation]
GO:1903679 [positive regulation of cap-independent translational initiation]
GO:1903898 [negative regulation of PERK-mediated unfolded protein response]
GO:1903912 [negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:1990441 [negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 377 aa
42.9 kDa 		No 0
NCK1-002
ENSP00000419631
ENST00000469404
P16333 [Direct mapping]
Cytoplasmic protein NCK1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005886 [plasma membrane]
GO:0007172 [signal complex assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008093 [cytoskeletal adaptor activity]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030674 [protein binding, bridging]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030971 [receptor tyrosine kinase binding]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042110 [T cell activation]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0060548 [negative regulation of cell death]
GO:0070262 [peptidyl-serine dephosphorylation]
GO:0071074 [eukaryotic initiation factor eIF2 binding]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903676 [positive regulation of cap-dependent translational initiation]
GO:1903679 [positive regulation of cap-independent translational initiation]
GO:1903898 [negative regulation of PERK-mediated unfolded protein response]
GO:1903912 [negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:1990441 [negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 313 aa
35.5 kDa 		No 0
NCK1-003
ENSP00000417273
ENST00000481752
P16333 [Direct mapping]
Cytoplasmic protein NCK1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004860 [protein kinase inhibitor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007015 [actin filament organization]
GO:0007172 [signal complex assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008093 [cytoskeletal adaptor activity]
GO:0012506 [vesicle membrane]
GO:0016477 [cell migration]
GO:0019904 [protein domain specific binding]
GO:0030032 [lamellipodium assembly]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030674 [protein binding, bridging]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030971 [receptor tyrosine kinase binding]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042110 [T cell activation]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051707 [response to other organism]
GO:0060548 [negative regulation of cell death]
GO:0070262 [peptidyl-serine dephosphorylation]
GO:0071074 [eukaryotic initiation factor eIF2 binding]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903676 [positive regulation of cap-dependent translational initiation]
GO:1903679 [positive regulation of cap-independent translational initiation]
GO:1903898 [negative regulation of PERK-mediated unfolded protein response]
GO:1903912 [negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:1990441 [negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 377 aa
42.9 kDa 		No 0
NCK1-004
ENSP00000419302
ENST00000491539
C9JVV5 [Direct mapping]
Cytoplasmic protein NCK1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 129 aa
14.9 kDa 		No 0
NCK1-005
ENSP00000419677
ENST00000485096
C9K098 [Direct mapping]
Cytoplasmic protein NCK1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 115 aa
13.2 kDa 		No 0
NCK1-006
ENSP00000418513
ENST00000476286
C9J0K5 [Direct mapping]
Cytoplasmic protein NCK1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 75 aa
8.8 kDa 		No 0
NCK1-009
ENSP00000417729
ENST00000488930
C9J869 [Direct mapping]
Cytoplasmic protein NCK1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 162 aa
18.4 kDa 		No 0
NCK1-010
ENSP00000419544
ENST00000496489
H7C5C7 [Direct mapping]
Cytoplasmic protein NCK1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 141 aa
16.1 kDa 		No 0
NCK1-011
ENSP00000418060
ENST00000467911
C9JAB9 [Direct mapping]
Cytoplasmic protein NCK1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 174 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.