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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AAED1
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AAED1

Gene description

AhpC/TSA antioxidant enzyme domain containing 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA021294
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA021294

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues were weakly stained or negative. Renal cancers displayed moderate cytoplasmic staining.

GENE INFORMATION

Gene name

AAED1 (HGNC Symbol)

Synonyms

C9orf21

Description

AhpC/TSA antioxidant enzyme domain containing 1 (HGNC Symbol)

Entrez gene summary

Chromosome

9

Cytoband

q22.33

Chromosome location (bp)

96639577 - 96655303

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158122 (version 83.38)

Entrez gene

195827

UniProt

Q7RTV5 (UniProt - Evidence at transcript level)

neXtProt

NX_Q7RTV5

Antibodypedia

AAED1 antibodies

PROTEIN BROWSER

AAED1-001
AAED1-002
AAED1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AAED1-001
ENSP00000398933
ENST00000446045
H0Y5J5 [Direct mapping]
Thioredoxin-like protein AAED1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
180 aa
20.1 kDa
No 0
AAED1-002
ENSP00000364382
ENST00000375234
Q7RTV5 [Direct mapping]
Thioredoxin-like protein AAED1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
226 aa
24.9 kDa
No 0
AAED1-003
ENSP00000412378
ENST00000411939
H0Y7F1 [Direct mapping]
Thioredoxin-like protein AAED1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
110 aa
12.6 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.