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Tissue enhanced (breast, duodenum, liver, small intestine)
GTEx:
Tissue enhanced (liver, small intestine)
FANTOM5:
Group enriched (colon, liver, small intestine)
Protein evidence
Evidence at protein level
Protein expression
Cytoplasmic expression with additional plasma positivity in lactating breast.
DATA RELIABILITY
Data reliability description
No internal RNA expression data available for correlation. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
RNA tissue category: Tissue enhanced (breast, duodenum, liver, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, liver, small intestine)
GENE INFORMATION
Gene name
XDH (HGNC Symbol)
Synonyms
XO, XOR
Description
Xanthine dehydrogenase (HGNC Symbol)
Entrez gene summary
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001933 [negative regulation of protein phosphorylation] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0003824 [catalytic activity] GO:0004854 [xanthine dehydrogenase activity] GO:0004855 [xanthine oxidase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005777 [peroxisome] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006195 [purine nucleotide catabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007595 [lactation] GO:0009055 [electron carrier activity] GO:0009115 [xanthine catabolic process] GO:0010629 [negative regulation of gene expression] GO:0016491 [oxidoreductase activity] GO:0016529 [sarcoplasmic reticulum] GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors] GO:0016903 [oxidoreductase activity, acting on the aldehyde or oxo group of donors] GO:0030856 [regulation of epithelial cell differentiation] GO:0042803 [protein homodimerization activity] GO:0043546 [molybdopterin cofactor binding] GO:0044281 [small molecule metabolic process] GO:0045602 [negative regulation of endothelial cell differentiation] GO:0046872 [metal ion binding] GO:0050660 [flavin adenine dinucleotide binding] GO:0051536 [iron-sulfur cluster binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1900745 [positive regulation of p38MAPK cascade] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001213 [negative regulation of vasculogenesis]
