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MRAS

GENERAL INFORMATION

Gene name

 MRAS

Gene description

 Muscle RAS oncogene homolog

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (EFO-21)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA042728
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042728

GENE INFORMATION

Gene name

 MRAS (HGNC Symbol)

Synonyms

 M-RAs, R-RAS3, RRAS3

Description

 Muscle RAS oncogene homolog (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 3

Cytoband

 q22.3

Chromosome location (bp)

 138347648 - 138405534

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158186 (version 83.38)

Entrez gene

 22808

UniProt

 O14807 (UniProt - Evidence at protein level)

neXtProt

 NX_O14807

Antibodypedia

 MRAS antibodies

PROTEIN BROWSER
MRAS-001
MRAS-002
MRAS-003
MRAS-004
MRAS-007
MRAS-008
MRAS-201
MRAS-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRAS-001
ENSP00000289104
ENST00000289104
O14807 [Direct mapping]
Ras-related protein M-Ras
Q6FGP0 [Target identity:100%; Query identity:100%]
MRAS protein; Muscle RAS oncogene homolog, isoform CRA_a; cDNA FLJ42964 fis, clone BRSTN2013741, highly similar to Ras-related protein M-Ras
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007517 [muscle organ development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0070062 [extracellular exosome]
Show all
 208 aa
23.8 kDa 		No 0
MRAS-002
ENSP00000389682
ENST00000423968
O14807 [Direct mapping]
Ras-related protein M-Ras
Q6FGP0 [Target identity:100%; Query identity:100%]
MRAS protein; Muscle RAS oncogene homolog, isoform CRA_a; cDNA FLJ42964 fis, clone BRSTN2013741, highly similar to Ras-related protein M-Ras
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007517 [muscle organ development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0070062 [extracellular exosome]
Show all
 208 aa
23.8 kDa 		No 0
MRAS-003
ENSP00000419582
ENST00000464896
O14807 [Direct mapping]
Ras-related protein M-Ras
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007517 [muscle organ development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0070062 [extracellular exosome]
Show all
 132 aa
15.5 kDa 		No 0
MRAS-004
ENSP00000417092
ENST00000475711
C9J601 [Direct mapping]
Ras-related protein M-Ras
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 23 aa
2.3 kDa 		No 0
MRAS-007
ENSP00000417685
ENST00000494949
C9J8Q6 [Direct mapping]
Ras-related protein M-Ras
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 107 aa
12.6 kDa 		No 0
MRAS-008
ENSP00000418356
ENST00000474559
O14807 [Direct mapping]
Ras-related protein M-Ras
Q6FGP0 [Target identity:100%; Query identity:100%]
MRAS protein; Muscle RAS oncogene homolog, isoform CRA_a; cDNA FLJ42964 fis, clone BRSTN2013741, highly similar to Ras-related protein M-Ras
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007517 [muscle organ development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0070062 [extracellular exosome]
Show all
 208 aa
23.8 kDa 		No 0
MRAS-201
ENSP00000484586
ENST00000614350
O14807 [Direct mapping]
Ras-related protein M-Ras
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007517 [muscle organ development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0070062 [extracellular exosome]
Show all
 132 aa
15.5 kDa 		No 0
MRAS-202
ENSP00000481637
ENST00000621127
O14807 [Direct mapping]
Ras-related protein M-Ras
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007517 [muscle organ development]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030742 [GTP-dependent protein binding]
GO:0070062 [extracellular exosome]
Show all
 132 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.