Fields »
ABOUT
HELP
BLOG
CDC25C

GENERAL INFORMATION

Gene name

 CDC25C

Gene description

 Cell division cycle 25C

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB003800
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), colorectal cancer (favourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB003800

GENE INFORMATION

Gene name

 CDC25C (HGNC Symbol)

Synonyms

 CDC25, PPP1R60

Description

 Cell division cycle 25C (HGNC Symbol)

Entrez gene summary

 This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 138285265 - 138338355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158402 (version 83.38)

Entrez gene

 995

UniProt

 P30307 (UniProt - Evidence at protein level)

neXtProt

 NX_P30307

Antibodypedia

 CDC25C antibodies

PROTEIN BROWSER
CDC25C-001
CDC25C-002
CDC25C-003
CDC25C-004
CDC25C-005
CDC25C-006
CDC25C-007
CDC25C-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC25C-001
ENSP00000321656
ENST00000323760
P30307 [Direct mapping]
M-phase inducer phosphatase 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000087 [mitotic M phase]
GO:0000278 [mitotic cell cycle]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006470 [protein dephosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007283 [spermatogenesis]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050699 [WW domain binding]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
Show all
 473 aa
53.4 kDa 		No 0
CDC25C-002
ENSP00000392631
ENST00000415130
P30307 [Direct mapping]
M-phase inducer phosphatase 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000087 [mitotic M phase]
GO:0000278 [mitotic cell cycle]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006470 [protein dephosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050699 [WW domain binding]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
Show all
 400 aa
45.6 kDa 		No 0
CDC25C-003
ENSP00000424795
ENST00000513970
P30307 [Direct mapping]
M-phase inducer phosphatase 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000087 [mitotic M phase]
GO:0000278 [mitotic cell cycle]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006470 [protein dephosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050699 [WW domain binding]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
Show all
 473 aa
53.4 kDa 		No 0
CDC25C-004
ENSP00000425470
ENST00000514555
P30307 [Direct mapping]
M-phase inducer phosphatase 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000087 [mitotic M phase]
GO:0000278 [mitotic cell cycle]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006470 [protein dephosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050699 [WW domain binding]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
Show all
 443 aa
50.1 kDa 		No 0
CDC25C-005
ENSP00000427251
ENST00000503022
D6RJC2 [Direct mapping]
M-phase inducer phosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000087 [mitotic M phase]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005622 [intracellular]
GO:0006470 [protein dephosphorylation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 249 aa
27.3 kDa 		No 0
CDC25C-006
ENSP00000427105
ENST00000510119
D6RD20 [Direct mapping]
M-phase inducer phosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000087 [mitotic M phase]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005622 [intracellular]
GO:0006470 [protein dephosphorylation]
Show all
 170 aa
18.3 kDa 		No 0
CDC25C-007
ENSP00000423525
ENST00000514017
H0Y999 [Direct mapping]
M-phase inducer phosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000087 [mitotic M phase]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005622 [intracellular]
GO:0006470 [protein dephosphorylation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 258 aa
30 kDa 		No 0
CDC25C-201
ENSP00000345205
ENST00000348983
P30307 [Direct mapping]
M-phase inducer phosphatase 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000087 [mitotic M phase]
GO:0000278 [mitotic cell cycle]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006470 [protein dephosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008283 [cell proliferation]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050699 [WW domain binding]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
Show all
 400 aa
45.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.