Expression of AHCYL2 in cancer - Summary - The Human Protein Atlas

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AHCYL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AHCYL2
Gene description	Adenosylhomocysteinase-like 2
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (HDLM-2)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in assorted tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA053128
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053128

GENE INFORMATION
Gene name	AHCYL2 (HGNC Symbol)
Synonyms	KIAA0828
Description	Adenosylhomocysteinase-like 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	7
Cytoband	q32.1
Chromosome location (bp)	129225023 - 129430211
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158467 (version 83.38)
Entrez gene	23382
UniProt	Q96HN2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HN2
Antibodypedia	AHCYL2 antibodies

PROTEIN BROWSER

AHCYL2-001	AHCYL2-002	AHCYL2-003	AHCYL2-004	AHCYL2-006	AHCYL2-007	AHCYL2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AHCYL2-001 ENSP00000420459 ENST00000474594	Q96HN2 [Direct mapping] Adenosylhomocysteinase 3 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004013 [adenosylhomocysteinase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0033353 [S-adenosylmethionine cycle] Show all	508 aa 56.9 kDa	No	0
AHCYL2-002 ENSP00000413639 ENST00000446544	Q96HN2 [Direct mapping] Adenosylhomocysteinase 3 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004013 [adenosylhomocysteinase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0033353 [S-adenosylmethionine cycle] Show all	610 aa 66.6 kDa	No	0
AHCYL2-003 ENSP00000420801 ENST00000490911	Q96HN2 [Direct mapping] Adenosylhomocysteinase 3 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004013 [adenosylhomocysteinase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0033353 [S-adenosylmethionine cycle] Show all	508 aa 56.7 kDa	No	0
AHCYL2-004 ENSP00000419346 ENST00000466924	H0Y8B3 [Direct mapping] Adenosylhomocysteinase Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004013 [adenosylhomocysteinase activity] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0033353 [S-adenosylmethionine cycle] Show all	518 aa 58 kDa	Yes	0
AHCYL2-006 ENSP00000419717 ENST00000460109	C9JZV7 [Direct mapping] Adenosylhomocysteinase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0033353 [S-adenosylmethionine cycle] Show all	75 aa 8.6 kDa	No	0
AHCYL2-007 ENSP00000419608 ENST00000466993	C9K0S0 [Direct mapping] Adenosylhomocysteinase 3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004013 [adenosylhomocysteinase activity] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0033353 [S-adenosylmethionine cycle] Show all	183 aa 19.9 kDa	No	0
AHCYL2-012 ENSP00000315931 ENST00000325006	Q96HN2 [Direct mapping] Adenosylhomocysteinase 3 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004013 [adenosylhomocysteinase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0033353 [S-adenosylmethionine cycle] GO:0043005 [neuron projection] GO:0043231 [intracellular membrane-bounded organelle] Show all	611 aa 66.7 kDa	No	0

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