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CD1D

GENERAL INFORMATION

Gene name

 CD1D

Gene description

 CD1d molecule

Protein class

 Cancer-related genes
CD markers
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (small intestine, spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a group of tissues, including lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB016107
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, spleen)

GENE INFORMATION

Gene name

 CD1D

Synonyms

Description

 CD1d molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 158179947 - 158184896

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158473 (version 83.38)

Entrez gene

 912

UniProt

 P15813 (UniProt - Evidence at protein level)

neXtProt

 NX_P15813

Antibodypedia

 CD1D antibodies

PROTEIN BROWSER
CD1D-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD1D-001
ENSP00000357153
ENST00000368171
P15813 [Direct mapping]
Antigen-presenting glycoprotein CD1d
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
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GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005887 [integral component of plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016032 [viral process]
GO:0016045 [detection of bacterium]
GO:0030881 [beta-2-microglobulin binding]
GO:0030882 [lipid antigen binding]
GO:0030883 [endogenous lipid antigen binding]
GO:0030884 [exogenous lipid antigen binding]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042393 [histone binding]
GO:0045058 [T cell selection]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0048006 [antigen processing and presentation, endogenous lipid antigen via MHC class Ib]
GO:0048007 [antigen processing and presentation, exogenous lipid antigen via MHC class Ib]
GO:0050839 [cell adhesion molecule binding]
GO:0071723 [lipopeptide binding]
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 335 aa
37.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.